Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
320 mg
356%
Calcium (from Calcium Carbonate)
36 mg
3%
Grape Seed Extract (Vitis vinifera) (min. 90% Total Polyphenols)
100 mg
†
Top Medical Research Studies
4
We examined the relationship between vitamin C intake and the risk of developing kidney stones in a large cohort. This study included a significant number of participants: 156,735 women from the Nurses' Health Studies and 40,536 men from the Health Professionals Follow-up Study.
Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.
However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.
Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.
However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.
9.5
We set out to investigate whether high doses of intravenous vitamin C (IVC) could influence the formation of kidney stones. Our study involved 157 adult patients receiving IVC therapy at Integrated Health Options clinic over a 12-month period.
Throughout the study, we conducted regular check-ins with patients, specifically asking about any kidney stones they might have experienced, along with monitoring their renal function through blood tests. Despite some patients having a prior history of kidney stones, we found that none reported developing new stones during the study.
Interestingly, we also noted that the majority of participants showed stable renal function, as indicated by consistent serum creatinine levels and estimated glomerular filtration rates (eGFR). In summary, our findings suggest that IVC therapy does not appear to be associated with an increased risk of kidney stones.
Throughout the study, we conducted regular check-ins with patients, specifically asking about any kidney stones they might have experienced, along with monitoring their renal function through blood tests. Despite some patients having a prior history of kidney stones, we found that none reported developing new stones during the study.
Interestingly, we also noted that the majority of participants showed stable renal function, as indicated by consistent serum creatinine levels and estimated glomerular filtration rates (eGFR). In summary, our findings suggest that IVC therapy does not appear to be associated with an increased risk of kidney stones.
8
Vitamin C may reduce kidney stones
We explored the dietary habits of individuals from the National Health and Nutritional Examination Survey (NHANES) to see how certain foods might influence kidney stone formation.
Our focus was particularly on vitamin C and its potential role in preventing these painful stones. We looked at a diverse group of nearly 17,000 people, analyzing their dietary intake alongside their kidney health over a span of several years.
Interestingly, our findings highlighted a connection between higher vitamin C intake and reduced kidney stone risk. Specifically, we noted that individuals consuming 60 to 110 mg of vitamin C daily had a lower chance of forming stones, with an even greater protective effect observed in those exceeding that amount.
While we didn't find significant associations with many other dietary elements, our results suggest that increasing vitamin C intake might be beneficial. This points towards a need for further research on how vitamin C and other dietary factors interact in the context of kidney stone prevention.
Our focus was particularly on vitamin C and its potential role in preventing these painful stones. We looked at a diverse group of nearly 17,000 people, analyzing their dietary intake alongside their kidney health over a span of several years.
Interestingly, our findings highlighted a connection between higher vitamin C intake and reduced kidney stone risk. Specifically, we noted that individuals consuming 60 to 110 mg of vitamin C daily had a lower chance of forming stones, with an even greater protective effect observed in those exceeding that amount.
While we didn't find significant associations with many other dietary elements, our results suggest that increasing vitamin C intake might be beneficial. This points towards a need for further research on how vitamin C and other dietary factors interact in the context of kidney stone prevention.
Most Useful Reviews
8.8
Improves blood flow
I love it! This is a high-quality Grape Seed supplement that has aided me due to its antioxidants. I take it to enhance blood flow, kidney function, and combat free radicals. The capsule is small and easy to swallow.
8.8
Supports kidney health
Excellent! I recommend taking this for overall health and well-being. I truly believe it aids kidney function and helps with inflammation for me.
8.8
Great kidney supplement
My husband and I consider this a valuable addition to our daily vitamin regimen. He believes it's an effective supplement for supporting his kidneys. We have encountered no issues with taking this Grape Seed extract.
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
- All Researches
9.5
We set out to investigate whether high doses of intravenous vitamin C (IVC) could influence the formation of kidney stones. Our study involved 157 adult patients receiving IVC therapy at Integrated Health Options clinic over a 12-month period.
Throughout the study, we conducted regular check-ins with patients, specifically asking about any kidney stones they might have experienced, along with monitoring their renal function through blood tests. Despite some patients having a prior history of kidney stones, we found that none reported developing new stones during the study.
Interestingly, we also noted that the majority of participants showed stable renal function, as indicated by consistent serum creatinine levels and estimated glomerular filtration rates (eGFR). In summary, our findings suggest that IVC therapy does not appear to be associated with an increased risk of kidney stones.
Throughout the study, we conducted regular check-ins with patients, specifically asking about any kidney stones they might have experienced, along with monitoring their renal function through blood tests. Despite some patients having a prior history of kidney stones, we found that none reported developing new stones during the study.
Interestingly, we also noted that the majority of participants showed stable renal function, as indicated by consistent serum creatinine levels and estimated glomerular filtration rates (eGFR). In summary, our findings suggest that IVC therapy does not appear to be associated with an increased risk of kidney stones.
8
We examined the relationship between dietary antioxidant intake, particularly vitamin C, and the risk of developing kidney stones. Utilizing data from the National Health and Nutrition Examination Survey, we found that individuals with higher levels of antioxidants, as indicated by the Composite Dietary Antioxidant Index (CDAI), had lower odds of forming kidney stones.
Stone formers, those who have experienced kidney stones, typically had a lower CDAI, showcasing significant differences based on gender. An interesting aspect of our findings was that vitamin C stood out as having the strongest negative correlation with kidney stones, suggesting that increased intake may be beneficial.
The results indicated that those in moderate and high CDAI groups had reduced odds of experiencing kidney stones compared to the lowest group. This was reflected in the odds ratios, which showed a significant decrease for those with higher antioxidant consumption. Therefore, it seems that a diet rich in antioxidants, particularly vitamin C, could play a role in lowering kidney stone risks.
However, while our findings are promising, we emphasize the need for more in-depth cohort studies to further investigate this potential connection and confirm its causal nature.
Stone formers, those who have experienced kidney stones, typically had a lower CDAI, showcasing significant differences based on gender. An interesting aspect of our findings was that vitamin C stood out as having the strongest negative correlation with kidney stones, suggesting that increased intake may be beneficial.
The results indicated that those in moderate and high CDAI groups had reduced odds of experiencing kidney stones compared to the lowest group. This was reflected in the odds ratios, which showed a significant decrease for those with higher antioxidant consumption. Therefore, it seems that a diet rich in antioxidants, particularly vitamin C, could play a role in lowering kidney stone risks.
However, while our findings are promising, we emphasize the need for more in-depth cohort studies to further investigate this potential connection and confirm its causal nature.
8
Vitamin C may reduce kidney stones
We explored the dietary habits of individuals from the National Health and Nutritional Examination Survey (NHANES) to see how certain foods might influence kidney stone formation.
Our focus was particularly on vitamin C and its potential role in preventing these painful stones. We looked at a diverse group of nearly 17,000 people, analyzing their dietary intake alongside their kidney health over a span of several years.
Interestingly, our findings highlighted a connection between higher vitamin C intake and reduced kidney stone risk. Specifically, we noted that individuals consuming 60 to 110 mg of vitamin C daily had a lower chance of forming stones, with an even greater protective effect observed in those exceeding that amount.
While we didn't find significant associations with many other dietary elements, our results suggest that increasing vitamin C intake might be beneficial. This points towards a need for further research on how vitamin C and other dietary factors interact in the context of kidney stone prevention.
Our focus was particularly on vitamin C and its potential role in preventing these painful stones. We looked at a diverse group of nearly 17,000 people, analyzing their dietary intake alongside their kidney health over a span of several years.
Interestingly, our findings highlighted a connection between higher vitamin C intake and reduced kidney stone risk. Specifically, we noted that individuals consuming 60 to 110 mg of vitamin C daily had a lower chance of forming stones, with an even greater protective effect observed in those exceeding that amount.
While we didn't find significant associations with many other dietary elements, our results suggest that increasing vitamin C intake might be beneficial. This points towards a need for further research on how vitamin C and other dietary factors interact in the context of kidney stone prevention.
8
We examined how different forms of vitamin C affect kidney stones, specifically looking at hyperoxaluria, a key risk factor for stone formation. In our study, conducted as a randomized, double-blind, crossover trial, we compared the effects of traditional ascorbic acid with a formulation containing vitamin C and metabolites, known as Ester-C.
Our findings revealed that Ester-C significantly lowered urine oxalate levels compared to regular ascorbic acid. This is exciting because higher oxalate levels in urine can lead to kidney stones, and finding a formulation that mitigates this risk is important.
Although this study presents promising results, it's essential to note that further evaluation is necessary to fully understand these findings. We believe this is a novel insight into the potential of vitamin C to help prevent kidney stones, and we look forward to additional research in this area.
Our findings revealed that Ester-C significantly lowered urine oxalate levels compared to regular ascorbic acid. This is exciting because higher oxalate levels in urine can lead to kidney stones, and finding a formulation that mitigates this risk is important.
Although this study presents promising results, it's essential to note that further evaluation is necessary to fully understand these findings. We believe this is a novel insight into the potential of vitamin C to help prevent kidney stones, and we look forward to additional research in this area.
7
We sought to understand how varying levels of vitamin C, among other vitamins, affect the prevalence of kidney stones. Our research relied on comprehensive data from NHANES, which allowed us to evaluate the relationships between nine common vitamins and kidney stone conditions.
Through logistic regression and detailed cluster analysis, we discovered that high vitamin C intake can have a complex impact. While individuals with very high vitamin B6 and D levels showed a decrease in kidney stone issues, vitamin C presented a different picture. Initially, as vitamin C intake increased, the risk for kidney stones seemed to drop. However, after a certain threshold, that benefit waned, and we observed a potential increase in risk instead.
This means that while vitamin C can be beneficial in moderation, too much might not be the best for kidney health. Furthermore, we found that when combined with other vitamins, particularly in specific patterns, the protective effects against kidney stones enhanced, suggesting that overall dietary balance is crucial.
Our findings shed light on a nuanced relationship between vitamin C and kidney stones, emphasizing the importance of considering not just individual vitamins, but how they work together.
Through logistic regression and detailed cluster analysis, we discovered that high vitamin C intake can have a complex impact. While individuals with very high vitamin B6 and D levels showed a decrease in kidney stone issues, vitamin C presented a different picture. Initially, as vitamin C intake increased, the risk for kidney stones seemed to drop. However, after a certain threshold, that benefit waned, and we observed a potential increase in risk instead.
This means that while vitamin C can be beneficial in moderation, too much might not be the best for kidney health. Furthermore, we found that when combined with other vitamins, particularly in specific patterns, the protective effects against kidney stones enhanced, suggesting that overall dietary balance is crucial.
Our findings shed light on a nuanced relationship between vitamin C and kidney stones, emphasizing the importance of considering not just individual vitamins, but how they work together.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improves blood flow
I love it! This is a high-quality Grape Seed supplement that has aided me due to its antioxidants. I take it to enhance blood flow, kidney function, and combat free radicals. The capsule is small and easy to swallow.
8.8
Supports kidney health
Excellent! I recommend taking this for overall health and well-being. I truly believe it aids kidney function and helps with inflammation for me.
8.8
Great kidney supplement
My husband and I consider this a valuable addition to our daily vitamin regimen. He believes it's an effective supplement for supporting his kidneys. We have encountered no issues with taking this Grape Seed extract.
Frequently Asked Questions
8.8
Supports kidney health
Excellent! I recommend taking this for overall health and well-being. I truly believe it aids kidney function and helps with inflammation for me.
8.8
Great kidney supplement
My husband and I consider this a valuable addition to our daily vitamin regimen. He believes it's an effective supplement for supporting his kidneys. We have encountered no issues with taking this Grape Seed extract.
8.8
Improves blood flow
I love it! This is a high-quality Grape Seed supplement that has aided me due to its antioxidants. I take it to enhance blood flow, kidney function, and combat free radicals. The capsule is small and easy to swallow.
8
Vitamin C may reduce kidney stones
We explored the dietary habits of individuals from the National Health and Nutritional Examination Survey (NHANES) to see how certain foods might influence kidney stone formation.
Our focus was particularly on vitamin C and its potential role in preventing these painful stones. We looked at a diverse group of nearly 17,000 people, analyzing their dietary intake alongside their kidney health over a span of several years.
Interestingly, our findings highlighted a connection between higher vitamin C intake and reduced kidney stone risk. Specifically, we noted that individuals consuming 60 to 110 mg of vitamin C daily had a lower chance of forming stones, with an even greater protective effect observed in those exceeding that amount.
While we didn't find significant associations with many other dietary elements, our results suggest that increasing vitamin C intake might be beneficial. This points towards a need for further research on how vitamin C and other dietary factors interact in the context of kidney stone prevention.
Our focus was particularly on vitamin C and its potential role in preventing these painful stones. We looked at a diverse group of nearly 17,000 people, analyzing their dietary intake alongside their kidney health over a span of several years.
Interestingly, our findings highlighted a connection between higher vitamin C intake and reduced kidney stone risk. Specifically, we noted that individuals consuming 60 to 110 mg of vitamin C daily had a lower chance of forming stones, with an even greater protective effect observed in those exceeding that amount.
While we didn't find significant associations with many other dietary elements, our results suggest that increasing vitamin C intake might be beneficial. This points towards a need for further research on how vitamin C and other dietary factors interact in the context of kidney stone prevention.
8
We examined the relationship between dietary antioxidant intake, particularly vitamin C, and the risk of developing kidney stones. Utilizing data from the National Health and Nutrition Examination Survey, we found that individuals with higher levels of antioxidants, as indicated by the Composite Dietary Antioxidant Index (CDAI), had lower odds of forming kidney stones.
Stone formers, those who have experienced kidney stones, typically had a lower CDAI, showcasing significant differences based on gender. An interesting aspect of our findings was that vitamin C stood out as having the strongest negative correlation with kidney stones, suggesting that increased intake may be beneficial.
The results indicated that those in moderate and high CDAI groups had reduced odds of experiencing kidney stones compared to the lowest group. This was reflected in the odds ratios, which showed a significant decrease for those with higher antioxidant consumption. Therefore, it seems that a diet rich in antioxidants, particularly vitamin C, could play a role in lowering kidney stone risks.
However, while our findings are promising, we emphasize the need for more in-depth cohort studies to further investigate this potential connection and confirm its causal nature.
Stone formers, those who have experienced kidney stones, typically had a lower CDAI, showcasing significant differences based on gender. An interesting aspect of our findings was that vitamin C stood out as having the strongest negative correlation with kidney stones, suggesting that increased intake may be beneficial.
The results indicated that those in moderate and high CDAI groups had reduced odds of experiencing kidney stones compared to the lowest group. This was reflected in the odds ratios, which showed a significant decrease for those with higher antioxidant consumption. Therefore, it seems that a diet rich in antioxidants, particularly vitamin C, could play a role in lowering kidney stone risks.
However, while our findings are promising, we emphasize the need for more in-depth cohort studies to further investigate this potential connection and confirm its causal nature.
4
We explored the controversial relationship between vitamin C supplements, specifically ascorbic acid, and the risk of kidney stones. Our investigation included a systematic review of multiple studies up until March 2017 that looked at both men and women regarding their use of these supplements.
The findings revealed that men who took vitamin C supplements had a notably higher incidence of kidney stones compared to women. For instance, the analysis showed an increased risk in men with doses between 250 to 1499 mg per day, though higher doses (500 mg and above) did not significantly affect risk levels. Interestingly, women did not show any correlation between vitamin C intake and kidney stone formation at any dosage level examined.
Ultimately, our review suggests that while vitamin C may enhance kidney stone risk in men, it does not appear to affect women in the same way. Given these observations, more research is needed—specifically long-term studies and randomized controlled trials—to confirm these outcomes and enhance our understanding of vitamin C's role in kidney stone formation.
The findings revealed that men who took vitamin C supplements had a notably higher incidence of kidney stones compared to women. For instance, the analysis showed an increased risk in men with doses between 250 to 1499 mg per day, though higher doses (500 mg and above) did not significantly affect risk levels. Interestingly, women did not show any correlation between vitamin C intake and kidney stone formation at any dosage level examined.
Ultimately, our review suggests that while vitamin C may enhance kidney stone risk in men, it does not appear to affect women in the same way. Given these observations, more research is needed—specifically long-term studies and randomized controlled trials—to confirm these outcomes and enhance our understanding of vitamin C's role in kidney stone formation.
4
We examined the relationship between vitamin C intake and the risk of developing kidney stones in a large cohort. This study included a significant number of participants: 156,735 women from the Nurses' Health Studies and 40,536 men from the Health Professionals Follow-up Study.
Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.
However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.
Our findings revealed that total and supplemental vitamin C intake was linked to a higher risk of kidney stones in men, but there was no such association evident in women. Specifically, among men, those who consumed higher amounts of vitamin C had greater likelihoods of developing stones when compared to those with lower intakes.
However, dietary vitamin C did not show a connection with kidney stones in either men or women. This suggests that while supplements may pose risks for men, dietary sources of vitamin C might not have the same impact. Overall, the study indicates that we should be cautious about high vitamin C supplement consumption, especially for men, while highlighting that dietary intake appears safe.
8
We examined how different forms of vitamin C affect kidney stones, specifically looking at hyperoxaluria, a key risk factor for stone formation. In our study, conducted as a randomized, double-blind, crossover trial, we compared the effects of traditional ascorbic acid with a formulation containing vitamin C and metabolites, known as Ester-C.
Our findings revealed that Ester-C significantly lowered urine oxalate levels compared to regular ascorbic acid. This is exciting because higher oxalate levels in urine can lead to kidney stones, and finding a formulation that mitigates this risk is important.
Although this study presents promising results, it's essential to note that further evaluation is necessary to fully understand these findings. We believe this is a novel insight into the potential of vitamin C to help prevent kidney stones, and we look forward to additional research in this area.
Our findings revealed that Ester-C significantly lowered urine oxalate levels compared to regular ascorbic acid. This is exciting because higher oxalate levels in urine can lead to kidney stones, and finding a formulation that mitigates this risk is important.
Although this study presents promising results, it's essential to note that further evaluation is necessary to fully understand these findings. We believe this is a novel insight into the potential of vitamin C to help prevent kidney stones, and we look forward to additional research in this area.
References
- Huang A, Huang W, Ye Y, Liu L, Wang H, et al. High composite dietary antioxidant index is associated with reduced risk of kidney stones: a cross-sectional analysis of NHANES 2007-2020. Nutr Res. 2024;128:60. doi:10.1016/j.nutres.2024.06.006
- Zeng H, Liu Z, He Y, Chen H, He J, et al. Multivitamins co-intake can reduce the prevalence of kidney stones: a large-scale cross-sectional study. Int Urol Nephrol. 2024;56:2991. doi:10.1007/s11255-024-04021-9
- Liu Kot K, Labagnara K, Kim JI, Loloi J, Gupta K, et al. Evaluating the American Urologic Association (AUA) dietary recommendations for kidney stone management using the National Health And Nutritional Examination Survey (NHANES). Urolithiasis. 2023;51:60. doi:10.1007/s00240-023-01423-9
- Jiang K, Tang K, Liu H, Xu H, Ye Z, et al. Ascorbic Acid Supplements and Kidney Stones Incidence Among Men and Women: A systematic review and meta-analysis. Urol J. 2019;16:115. doi:10.22037/uj.v0i0.4275
- Prier M, Carr AC, Baillie N. No Reported Renal Stones with Intravenous Vitamin C Administration: A Prospective Case Series Study. Antioxidants (Basel). 2018;7. doi:10.3390/antiox7050068
- Ferraro PM, Curhan GC, Gambaro G, Taylor EN. Total, Dietary, and Supplemental Vitamin C Intake and Risk of Incident Kidney Stones. Am J Kidney Dis. 2016;67:400. doi:10.1053/j.ajkd.2015.09.005
- Modi J, Modi P, Pal B, Bansal J, Kumar S, et al. Role of Vitamin C and E supplementation in reduction of serum level of renal injury marker following shock wave lithotripsy: Prospective single centre experience. Urol Ann. 2015;7:350. doi:10.4103/0974-7796.156143
- Moyad MA, Combs MA, Crowley DC, Baisley JE, Sharma P, et al. Vitamin C with metabolites reduce oxalate levels compared to ascorbic acid: a preliminary and novel clinical urologic finding. Urol Nurs. 2009;29:95.
- Ran Y, Liu Z, Ma H, Li C, Zhou J, et al. Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies. Medicine (Baltimore). 2025;104:e41323. doi:10.1097/MD.0000000000041323
